Formulated by Dr. Nathan S. Bryan, PhD

Your Body Isn’t Making the Nitric Oxide It Used To.

N1o1 is designed to support your body’s declining nitric oxide production with science-backed nutritional, oral care, and skincare solutions, working from the inside out.

N1o1 complete range: nitric oxide lozenges, N.O. Beetz, Breath of Life toothpaste, gel cleanser, activating serum, eye cream and face cream

Press coverage

Men's Health
Dave Asprey
The Diary of a CEO
Forbes
VICTORY Men's Health
Lifespanning

N1o1 Nitric Oxide Lozenges

$59.98

  • Formulated by Dr. Nathan Bryan
  • Vegan
  • Gluten Free
  • Non-GMO
  • No harsh chemicals

Best Sellers

Meet the N1o1 lineup.

N1o1 nitric oxide nitric oxide nitric oxide signaling molecule

N1o1 Nitric Oxide Lozenges

$53.98

Releases nitric oxide as the lozenge dissolves in your mouth.

Breath of Life Nitric Oxide Boosting Toothpaste

Breath of Life Nitric Oxide Boosting Toothpaste

$23.74

Breath of Life supports the mouth’s natural nitric oxide pathway without fluoride.

N1o1 nitric oxide nitric oxide nitric oxide signaling molecule

N.O. Beetz Nitric Oxide Supplement

$55.98

Plant based, with fermented beetroot powder and patented PEAK ATP.

N1o1 nitric oxide nitric oxide nitric oxide signaling molecule

Nitric Oxide Activating Age-Defiance Serum

$95.98

A dual chamber formula that activates on contact, with Vitamin C and E.

N1o1 Nitric Oxide Lozenges Bundle (Buy 3 Get 1 Free)

N1o1 Nitric Oxide Lozenges Bundle (Buy 3 Get 1 Free)

$179.94

Buy three, get one free. Limited to one bundle per order.

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What the record shows

4.86 Average published customer ratingPublished customer reviews via Judge.me.
376 Published customer reviewsPublished customer reviews via Judge.me.
30+ Years Dr. Bryan has worked on nitric oxideStated in his published bio on n1o1.com
6 Books on nitric oxide authored or edited by the founderDr. Bryan's published bio; two of the six are carried here

Creators and clinicians

Dr. Natalie Ledbetter, @drnatalieledbetter

Bauman Medical, @baumanmedical, on the serum for scalp care

@emiliavlogs on N.O. Beetz

Brianna Prather, medical aesthetician at @chernoffcosmeticsurgery, on the skincare system

See N1o1 in real life.

@n1o1life

How the pathway works

From food to circulation. Follow the nitric oxide pathway.

  1. Stage 01

    Eat

    Leafy greens and beets provide dietary nitrate.

  2. Stage 02

    Convert

    Bacteria on your tongue convert nitrate into nitrite.

  3. Stage 03

    Release

    Nitrite converts into nitric oxide in your tissues.

  4. Stage 04

    Signal

    Nitric oxide signals blood vessel walls to relax.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

A couple brushing their teeth with N1o1 Breath of Life nitric oxide toothpaste

Built for daily routines

Keep doing more of what keeps you, you.

Build nitric oxide support into the routines you already have.

Start with the molecule

Nitric oxide is a signalling molecule the body makes itself. Its best understood job is telling blood vessels to relax and widen.

A signalling molecule

Nitric oxide carries a message between cells. It tells the smooth muscle in vessel walls to relax.

Output falls with age

The body's own nitric oxide production declines with age. That is the gap every product here is aimed at.

The mouth matters

N1o1 offers dissolving lozenges and a beet powder drink. Healthy oral bacteria also play a role in the body’s natural nitrate-to-nitric-oxide pathway.

Three delivery routes

A lozenge that dissolves in the mouth, a toothpaste that protects the oral pathway, and topicals for skin.

N1o1 in the press

Dr. Nathan Bryan and the science of nitric oxide, in the press.

Forbes on nitric oxide innovation in biotechnology

Forbes on nitric oxide innovation in biotechnology

Dr. Nathan S. Bryan with Amy Stuttle on VICTORY Men's Health

Dr. Nathan S. Bryan with Amy Stuttle on VICTORY Men's Health

Your Optimal Health on Now Media TV

Your Optimal Health on Now Media TV

Named to the Lifespanning Top 50 Leaders list

Named to the Lifespanning Top 50 Leaders list

Formulated by Dr. Nathan S. Bryan, PhD

What makes N1o1 different

N1o1 lozenges next to two common nitric oxide formats, compared on format, ingredients and pathway.

Feature
Bottle of N1o1 Nitric Oxide Releasing Lozenges, 60 count

N1o1

Nitric Oxide Lozenges

Lozenge
Illustration of a beetroot powder drink with a scoop

Typical beet powder

Powder drink
Illustration of unbranded capsules

Typical nitrate capsule

Capsule
Dissolves in the mouth
Yes:Dissolves over about 5 to 6 minutes
No:Typically mixed into water and drunk
No:Typically swallowed whole with water
Nitrite named on the label
Yes:Sodium nitrite, in the 220 mg blend
Typically beetroot, a dietary nitrate source
Typically a nitrate salt or plant nitrate
Pathway stage it supplies
Yes:Nitrite, the step before nitric oxide in N1o1's pathway
Typically nitrate, which the body turns into nitrite
Typically nitrate, which the body turns into nitrite
No cane sugar or syrup listed
Yes:Sweetened with mannitol, stevia and monk fruit
Typically some natural sugar from the beets
Yes:Typically no sugar or syrup

Comparison reflects common product types in each category, based on publicly available labels, November 2026. Formulas vary by brand; read the label on any product you take. Images in the other columns illustrate the format only.

  1. N1o1 product page: n1o1.com/product/n1o1-nitric-oxide-lozenges
  2. N1o1 article: n1o1.com/best-nitric-oxide-supplements

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Dr. Nathan S. Bryan

With over 30 years of nitric oxide research, Dr. Bryan personally formulates the N1o1 collection, science-backed nutritional supplements, oral care, and advanced skincare designed to support your body's nitric oxide system from the inside out.

Dr. Nathan S. Bryan presenting the N1o1 product lineup

Dr Nathan Bryan talks N1o1

The science, in his own words. Watch the full conversations.

The Untold Truth About Nitric Oxide and Health

The Diary of a CEO

The Untold Truth About Nitric Oxide and Health

Hosted on Dr. Nathan Bryan's own channel, May 2025

How Nitric Oxide Controls Oxygen and Nutrient Delivery, Aging and Quality of Life

The Human Upgrade

How Nitric Oxide Controls Oxygen and Nutrient Delivery, Aging and Quality of Life

Dave Asprey, episode 1041, April 2023

Nitric Oxide and Functional Health

The Empowering Neurologist

Nitric Oxide and Functional Health

David Perlmutter MD, episode 166, June 2023

Find your routine

Find your N1o1 starting point

Choose the routine you want to build. We will show you the clearest place to begin.

Recommended starting point

Start with supplements

N1o1 lozenges release nitric oxide as they dissolve in the mouth. NO Beetz adds a fermented beetroot powder option.

Shop supplements

60-day money-back guarantee

N1o1 offers a 60-day money-back guarantee on all orders. The 60-day return window begins the day your order is received. Shipping charges for your original purchase are non-refundable. Please allow up to 30 days for returns to be processed. Read the Shipping and Returns Policy for exclusions and return instructions.

Shipping and Returns Policy

Start with the science

Nitric oxide is one of the most studied molecules in cardiovascular medicine, and one of the least understood outside it. Two places to begin.

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What customers have to say

4.86 / 5 Across 376 published customer reviews

Questions

The ones we are asked most. If yours is not here, ask us.

Ask a question
What is nitric oxide?

A signalling molecule the body produces itself. Its best understood role is telling the smooth muscle in blood vessel walls to relax, which widens the vessel.

Who formulates these products?

Dr. Nathan S. Bryan, PhD, a nitric oxide researcher who has worked in the field for more than thirty years. He has authored or edited six books, two of which are carried in this catalog.

Where should I start?

Most people start with the lozenges. It is the most reviewed product in the range.

Is the range only supplements?

No. It covers supplements, oral care and the Age-Defiance skincare line, plus bundles that group them.

How long does one bottle of lozenges last?

Each bottle holds 60 lozenges. N1o1 recommends one lozenge twice a day, 12 hours apart, so one bottle is a 30-day supply. Follow the directions on your current bottle.

Why is there a toothpaste in a nitric oxide range?

Because one stage of the pathway happens in your mouth. Bacteria on the back of the tongue perform a conversion the human body cannot do on its own, and antiseptic mouthwash disrupts them. The toothpaste is built to work with those bacteria rather than against them, which is also why it uses hydroxyapatite rather than fluoride.

What is the difference between the lozenges and N.O. Beetz?

The lozenge gives a sustained release and is the most reviewed product in the range. N.O. Beetz is a fermented beetroot powder you mix into water, it is oxalate-free, and it carries none of the usual beet taste or colour. Space the two at least four hours apart.

Can I take these alongside other supplements or medication?

Check with your healthcare provider first. That is the honest answer rather than a reassuring one. If you have low blood pressure or take medication, have that conversation before you start.

Where does the range start and where does it go?

Most people start with the lozenges, add the toothpaste to protect the oral step, and move into the Age-Defiance skincare if they want the same chemistry applied topically. Nothing requires anything else to work.